Naked Snake/Big Boss. The world's greatest soldier can only be fucked around by governments and spies so many times before he decides to show them who the Boss is. From Metal Gear.
Postal Guy. The world is an annoying place full of assholes and idiots, and he's had enough of them. From Postal.
Raziel. After a thousand years of loyal service to his vampire lord his reward was having his new wings torn off and being thrown into a lake, where the water burned his vampire skin away like acid. He wasn't happy about it. From Legacy of Kain - Soul Reaver.
Sander Cohen. An eccentric artist driven even more crazy by drugs and people just not appreciating his work. From Bioshock.

the rest of those guys dont deserve to be in the same vote.

I'm tempted to vote for Raziel, and cause a second vote.

But nah.